Endothelial cell secreted VEGF-C enhances NSC VEGFR3 expression and promotes NSC survival
نویسندگان
چکیده
منابع مشابه
Cell autonomous Vegf-C/Vegfr3 signaling in adult neural stem cells
In the adult mammalian brain, the potential to generate new neurons is restricted to a limited number of sites, called neurogenic niches, which are mainly the subventricular zone lining the cerebral ventricles and the dentate gyrus of the hippocampus. Neurogenic niches harbor a unique population of neural stem cells (NSCs), self-renewing cells with hallmarks of astrocytes that generate neurons ...
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Vascular endothelial growth factor (VEGF)-A is an autocrine survival factor for podocytes, which express two VEGF receptors, VEGF-R1 and VEGF-R3. As VEGF-A is not a known ligand for VEGF-R3, the aim of this investigation was to examine whether VEGF-C, a known ligand for VEGF-R3, served a function in podocyte biology and whether this was VEGF-R3 dependent. VEGF-C protein expression was localized...
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ژورنال
عنوان ژورنال: Stem Cell Research
سال: 2021
ISSN: 1873-5061
DOI: 10.1016/j.scr.2021.102318